The Compositional Nature of Event Representations in the Human Brain

How does the human brain represent simple compositions of constituents: actors, verbs, objects, directions, and locations? Subjects viewed videos during neuroimaging (fMRI) sessions from which sentential descriptions of those videos were identified by decoding the brain representations based only on their fMRI activation patterns. Constituents (e.g., fold and shirt) were independently decoded from a single presentation. Independent constituent classification was then compared to joint classification of aggregate concepts (e.g., fold-shirt); results were similar as measured by accuracy and correlation. The brain regions used for independent constituent classification are largely disjoint and largely cover those used for joint classification. This allows recovery of sentential descriptions of stimulus videos by composing the results of the independent constituent classifiers. Furthermore, classifiers trained on the words one set of subjects think of when watching a video can recognise sentences a different subject thinks of when watching a different video

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.

Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs\u27 therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less frequently. The majority of irAEs are mild to moderate in severity; however, serious and occasionally life-threatening irAEs are reported in the literature, and treatment-related deaths occur in up to 2% of patients, varying by ICI. Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. There is an urgent need for multidisciplinary guidance reflecting broad-based perspectives on how to recognize, report and manage organ-specific toxicities until evidence-based data are available to inform clinical decision-making. The Society for Immunotherapy of Cancer (SITC) established a multidisciplinary Toxicity Management Working Group, which met for a full-day workshop to develop recommendations to standardize management of irAEs. Here we present their consensus recommendations on managing toxicities associated with immune checkpoint inhibitor therapy

Secularism, Racism and the Politics of Belonging

This collection of papers is a reflection of an ongoing debate about the relationships between religion, the citizen and the state. It is a debate that is far from settled, and indeed one which may be unsettling, but a debate which too often generates more heat than light. It is, however, a crucial discussion since it goes to the heart of our understanding of modern citizenship, the role of the state and the struggle for equality. Runnymede was especially pleased to partner with colleagues at the Centre for Refugees, Migration and Belonging (CRMB) at the University of East London in co-hosting the two conferences from which these papers are drawn. CRMB’s serious and engaged approach to relating political theory to political action enabled academics, commentators and practitioners to share a platform where disagreements were aired and constructive debate and discussion enabled. We hope that the conferences act as a model for the deliberations which are necessary to address the thorny challenges raised by the authors. Many of these disagreements are reflected in the papers presented here. The collected papers discuss faith-based schooling, the veil, honour based violence, religious arbitration, and the delivery of public services by faith communities. All of these issues remain very much alive in contemporary public policy debates in the UK and beyond

Time- but not sleep-dependent consolidation promotes the emergence of cross-modal conceptual representations

Conceptual knowledge about objects comprises a diverse set of multi-modal and generalisable information, which allows us to bring meaning to the stimuli in our environment. The formation of conceptual representations requires two key computational challenges: integrating information from different sensory modalities and abstracting statistical regularities across exemplars. Although these processes are thought to be facilitated by offline memory consolidation, investigations into how cross-modal concepts evolve offline, over time, rather than with continuous category exposure are still missing. Here, we aimed to mimic the formation of new conceptual representations by reducing this process to its two key computational challenges and exploring its evolution over an offline retention period. Participants learned to distinguish between members of two abstract categories based on a simple one-dimensional visual rule. Underlying the task was a more complex hidden indicator of category structure, which required the integration of information across two sensory modalities. In two experiments we investigated the impact of time- and sleep-dependent consolidation on category learning. Our results show that offline memory consolidation facilitated cross-modal category learning. Surprisingly, consolidation across wake, but not across sleep showed this beneficial effect. By demonstrating the importance of offline consolidation the current study provided further insights into the processes that underlie the formation of conceptual representations

Is maximising creativity good? The importance of elaboration and internal confidence in producing creative ideas

While knowledge management researchers acknowledge that individuals transition from generation to implementation of ideas, these transitions are not fully understood. The current article focuses on idea elaboration–defined as the transition of an idea from an individual’s mind to one that is expressed in a work context–as a critical step towards creative output–the number of creative ideas an individual generates. Several related hypotheses were explored with a psychologically realistic simulation of creativity. A total of 100,000 trials of the creativity task was simulated to examine the relationship between creativity and creative output. Results suggest that low degrees of creativity combined with the elaboration of conventional ideas may lead to a greater number of creative ideas. The current article contributes to the field of knowledge management by leveraging the dynamics of cognition and stressing the importance of idea elaboration and the role that internal confidence plays